Applications have opened for operators to run taxi, bus and private hire-style self-driving vehicles.
Passengers could be able to book taxi and bus-style self-driving vehicles later this year.
The pilot scheme will enable firms to bring cutting-edge technology to British roads, creating thousands of jobs and unlocking billions for the economy by 2035.
It is hoped the services could enhance journeys by supporting greater freedom and independence for older and disabled people.
The government has highlighted that safety will be central to the pilot scheme and services will be subject to rigorous approval checks.
Local transport authorities will also need to provide local consent to ensure services reflect local priorities.